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Did you know methadone is the medication with the longest history of use for opioid use disorder treatment, having been used since 1947?. Methadone is also used as a pain reliever and also as part of drug addiction detox and maintenance programs. 

In this topic, we will be discussing what is methadone, how it works, warnings, and side effects. Most importantly we did outline what other drugs can affect methadone consumption and the relationship it has with Ibogaine.

Table of Contents

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What is methadone?

Methadone is a medication for persons suffering from opioid addiction. An opioid also is sometimes called a narcotic. However, Methadone is a medication that reduces withdrawal symptoms in persons addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction.

Also, it is also used as a pain reliever and also as part of drug addiction detox and maintenance programs. It is available only from a certified pharmacy. Methadone is an around-the-clock treatment of severe pain.

How Does Methadone Work?

To begin, methadone is a medication against opioid addiction that works on the brain by binding to the same receptors as other opioid drugs like heroin or OxyContin. Since methadone is a drug that remains in the body for a long period of time, typically 1-3 days – it helps greatly to block euphoric effects of other opiate drug abuse and lessen painful symptoms of withdrawal from these drugs.

Nonetheless, methadone is such a long-acting medication, designed to ease symptoms in people addicted to heroin for 1-2 days, it can therefore build up quickly in the body and remain in the bloodstream for a long time. For this reason, it is important for individuals with methadone prescriptions to use this medication exactly as prescribed, and not to adjust their own dose without a health care provider’s advice and oversight. This is because it is easy to overdose on methadone due to the strength of one dose.

Warnings (Contraindications)

The following warning should be taken seriously especially for those using methadone or planning to medicate on methadone:

  • If you are suffering from severe asthma or breathing problems, or a blockage in your stomach or intestines, you should avoid the use of methadone.
  • MISUSE OF METHADONE has its consequences and CAN lead to ADDICTION, OVERDOSE, OR DEATH, especially in children or other person using the medicine without a prescription from a medical practitioner. Also, make sure to keep the medication in a place where others cannot get to it.
  • Using medicine for opioids during your pregnancy may lead to life-threatening withdrawal symptoms in the newborn baby.
  • Using opioid medicine with alcohol may cause some fatal side effects, or with other drugs that cause drowsiness or slow down your breathing.
  • Methadone use may lead to a life-threatening heart rhythm disorder. Call your health care provider at once if you experience a headache with chest pain and severe dizziness, and a fast or pounding heartbeat. Your heart function may need to be checked during the opioid treatment using methadone.
What other drugs will affect methadone?

There are risks you may have a fatal methadone overdose if you just started or stopped using certain other medicines. Always make sure to tell your health care provider about all your medications. Several other drugs can be dangerous when used with opioid medicine. Tell your health care provider if you also use the following drugs or medications:

  • If you use medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder;
  • If you use other opioid medicines;
  • If you use a benzodiazepine sedative like Valium, Klonopin, or Xanax;
  • If you use sleep medicine, muscle relaxers, or other drugs that make you drowsy; or
  • Also, drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson’s disease.


N/B: This list is not complete. There are other drugs however that may affect methadone treatment for opioids, including prescription and over-the-counter medicines, vitamins, and herbal products. Take note that not all possible interactions are listed here.

Methadone Side Effects

These side effects of using Methadone are similar to those associated with other opioid drugs. These will include:

  • Constipation
  • Lightheadedness or dizziness
  • Sleepiness or drowsiness
  • Nausea or vomiting
  • Impaired cognition or confusion
  • Forgetfulness
  • Impaired balance or coordination
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Methadone Overdose Symptoms

It is much easier and common to overdose on methadone than other opioid drugs. This is especially if methadone is used recreationally or without the supervision of a competent medical health provider. Symptoms of a methadone overdose include:

  • Slow, shallow breathing, known as respiratory depression
  • Clammy or bluish skin
  • Blue-tinted lips and fingertips
  • Extreme fatigue to the point of being unable to stay awake
  • Stupor
  • Convulsions
  • Vomiting
  • Coma
  • Death

Whether in prescription or illegal drugs, mixing methadone with other medications or drugs can lead to serious heart problems as well. These heart problems range from arrhythmia to heart attack.


As a way of concluding this article, After an ibogaine dose, when symptoms of opioid withdrawal appear again, half of the methadone dose used last time will be administered. By doing so, methadone doses will be progressively reduced until no withdrawal symptoms appear. Ibogaine Hydrochloride 100 mg on each administration

Let us know what you think of this, which of these treatment methods works for you. Let us know in the comment section below.