Studies on the Use of Ibogaine to Treat Heroin Withdrawal

Some Case Studies Involving the Treatment of Heroin Withdrawal with Ibogaine

Studies on the Use of Ibogaine to Treat Heroin Withdrawal

Due to its ability to treat addiction, ibogaine is considered a promising treatment for heroin withdrawal and drug addiction, including alcohol abuse.

However, as with any drug, there are potential side effects and complications that make ibogaine less than ideal for some people.

In this article, we will explore the possible benefits and risks of using ibogaine as an opioid detoxification treatment and look at case studies involving the use of ibogaine for opiate withdrawal management. Controlled clinical trials are needed to validate the effectiveness and safety of ibogaine.

Heroin is an opioid drug that produces effects similar to those of morphine and other opiates. FDA approval is crucial for the use of ibogaine in treating addiction to ensure its safety and efficacy against substance use abuse.

The pharmacological effects of heroin are similar to those of other opioids, including analgesia and euphoria (euphoria is a feeling of intense happiness).

What is Heroin?

Heroin is an opioid drug derived from morphine, a natural substance extracted from the seed pod of the opium poppy plant. Known for its potent psychoactive effects, heroin induces intense euphoria and analgesia, making it highly addictive. The drug is commonly used recreationally for its rapid onset of euphoric effects, which occur due to its ability to bind to and activate opioid receptors in the brain.

Key Characteristics of Heroin:

  1. Opioid Dependence and Drug Addiction: Heroin use can quickly lead to opioid dependence and drug addiction, classified as substance use disorders. The addictive nature of heroin is due to its impact on the brain’s reward system, leading to compulsive drug-seeking behavior despite harmful consequences.

  2. Withdrawal Symptoms: Individuals addicted to heroin experience severe withdrawal symptoms when they attempt to quit. These symptoms include intense drug cravings, nausea, vomiting, diarrhea, insomnia, anxiety, and depression.

  3. Substance Abuse and Use Disorders: Heroin abuse contributes significantly to the global burden of substance use disorders. The risk of overdose and death is high due to its potent effects and the variability in street-level purity.

  4. Research and Observational Data: Recent observational studies and research on ibogaine have provided evidence of its efficacy in treating addiction. However, further research and FDA approval are needed to ensure its safety and effectiveness.

Case Study 1: Ibogaine therapy

In this particular case, a patient who had been using heroin for many years was admitted to an ibogaine treatment center.

He presented with symptoms of withdrawal and detoxification syndrome (including vomiting, diarrhea, insomnia, and dysphoria).

After receiving a dose of ibogaine, he noticed that his withdrawal symptoms had improved significantly. Ibogaine acts as a non-competitive NMDA receptor antagonist, suppressing withdrawal symptoms and affecting multiple targets throughout the body associated with substance use disorder.

Ibogaine administration has shown positive effects on opioid withdrawal symptoms, helping patients manage their cravings and reducing the likelihood of relapse.

He reported zero cravings for heroin and was able to return to work after his treatment session. His follow-up interviews showed no signs of relapse or further drug use.

Case study 2: Opioid dependence

A 17-year-old male was admitted to the clinic on day 5 of heroin detoxification. He had been taking heroin for 8 months before coming in and had been detoxing from it in the clinic’s detox room for 5 days at the time of admission.

He reported that his withdrawal symptoms were severe, but not life-threatening; he did not have any history of seizures or delirium tremens (DTs).

The patient was given ibogaine hydrochloride 500 mg intramuscularly (IM), and approximately 20 minutes later he began reporting feeling nauseous and hot while lying in bed with his eyes closed.

The nurse noted that the patient appeared uncomfortable but otherwise stable.

Ibogaine interacts with opioid receptors to alleviate withdrawal symptoms. After approximately 90 minutes without any change in his condition, we gave him another dose, but this time 100 mg IM, and noticed that his anxiety level went down significantly after about 30 minutes, although he still seemed somewhat uncomfortable due to sweating profusely despite being cold at this point as well as having a dry mouth which made swallowing difficult.

Case study 3: Substance use disorders

Case study 3 talks about a 19-year-old female heroin addict for 2 years, who had been in and out of detox and rehab facilities, and tried methadone, Suboxone, as well as other medications to help her withdraw from heroin.

She also tried various treatment modalities that involved psychotherapy and holistic modalities including acupuncture. She had been using 2 grams of heroin per day for the last 6 months before she sought ibogaine treatment at an ibogaine center in Mexico. Ibogaine is considered a potential treatment for addiction due to its complex pharmacological mechanisms and ability to reduce substance craving.

This patient was able to safely detox from opiates during her initial stay at the clinic by taking an SQ injection of 5mg/kg of ibogaine HCL once daily for three days followed by 4 mg/kg daily thereafter until her cravings were gone (about 4 weeks total). Ibogaine has shown promise in treating substance use disorders, including alcohol and opioid dependence, by providing transformative psychological insights and reducing intake.

After this time, she returned home where she received another injection every three days until all withdrawal symptoms and cravings were resolved (about a month in total).

Case study 4

This is a case study of one patient who was in a treatment program for heroin addiction and had been using heroin for 20 years.

The patient was experiencing severe withdrawal symptoms when he received ibogaine, but the symptoms were not present after taking ibogaine.

Ibogaine is a psychoactive drug that has been used as an alternative treatment to opioid dependence. To ensure patient safety, clinical laboratory values were evaluated, side effects were monitored, and vital signs were closely observed post-administration.

It has been reported to have anti-addiction properties, helping people recover from their addiction by reducing cravings and minimizing withdrawal symptoms.

The patient described below was given ibogaine while experiencing severe withdrawal symptoms from heroin use; they also experienced no withdrawal symptoms while using this psychoactive drug.


At this point, ibogaine treatments have been proven to be effective in the treatment of heroin withdrawal symptoms. However, it is not a cure for addiction or drug abuse. Ibogaine is not a magic bullet; it is just one tool that can help those who are struggling with heroin withdrawal.

Ibogaine can also be used to treat substance abuse, addressing issues related to cocaine and opioid dependence. Evidence-based care is crucial for treating substance abuse, and ibogaine can play a role in comprehensive rehabilitation programs.

Although ibogaine has been used safely and successfully in studies around the world with thousands of patients, there are still risks associated with its use as well as potential complications that may occur during treatment.

In addition to these side effects, there are also other factors such as individual genetics and medical history which can affect how well someone responds to ibogaine treatment during their withdrawal period and beyond.

Takeaway: Clinical trials

Ibogaine appears to be a promising treatment for opioid use disorder, including heroin withdrawal. Ibogaine is a psychoactive chemical found in the root bark of the iboga plant. It has been used historically as a treatment for addiction to heroin and other substances, and it appears to be a promising treatment for heroin withdrawal.

In this case study, an individual with opiate dependence who had tried traditional treatments such as naltrexone but hadn’t been able to completely stop using drugs sought out ibogaine therapy at an underground clinic in Mexico.

The patient took ibogaine under supervision from medical professionals and experienced no adverse effects related to the treatment.

He reported reduced cravings for opiates after taking ibogaine, which allowed him to stop using heroin without experiencing severe withdrawals when he returned home from Mexico.


In conclusion, it is important to note that the treatment of substance use disorders, including heroin withdrawal, with ibogaine remains an experimental procedure.

However, there are several case studies out there supporting its use as well as some research that can be used for further advances in this field. Psychoactive drugs like ibogaine have shown potential in treating addiction by affecting the user’s perception, thought, and consciousness.

With more studies being done each day and new information coming out about how ibogaine works on the brain, we may someday see more widespread use of this therapy in the future.

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Get Ibogaine Team is the collective expertise behind Get Ibogaine, a leading provider of iboga products and addiction treatment services.

With over 200 successful cases since 2017, our team comprises certified naturopathic practitioners, iboga experts, doctors, and Lab Technicians dedicated to helping individuals heal from addiction.

From aiding individuals in overcoming addiction to guiding seekers on transformative spiritual experiences rooted in the Bwiti tradition, we bring passion, experience, and holistic solutions to every aspect of our work.

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Miracle and amazement

April 14, 2024

Ibogaine is just a blessing from the sky. I am so grateful that I came across it. I have been using it for one month and it has been just an amazing journey. Have I already mentioned that I am grateful? Yes, I truly am. The purchase was easy, and I was guided throughout the process. The product arrived on time and was guided on how to microdose it. I feel balanced in my soul, mind, and body. What a miracle. I believe everybody should know about Ibogaine. I highly recommend it. Everybody should use it. We all need it.

Thank you so much and very grateful.


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